Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4346930..4347623 Replicon chromosome
Accession NZ_CP109953
Organism Escherichia coli strain NC22

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag OI124_RS21070 Protein ID WP_000415584.1
Coordinates 4346930..4347226 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag OI124_RS21075 Protein ID WP_000650107.1
Coordinates 4347228..4347623 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI124_RS21040 (4342605) 4342605..4342919 - 315 WP_000958598.1 putative quinol monooxygenase -
OI124_RS21045 (4342950) 4342950..4343531 - 582 WP_278136992.1 NADPH:quinone oxidoreductase MdaB -
OI124_RS21050 (4343641) 4343641..4344990 - 1350 WP_000673406.1 quorum sensing histidine kinase QseC -
OI124_RS21055 (4344987) 4344987..4345646 - 660 WP_001221491.1 quorum sensing response regulator transcription factor QseB -
OI124_RS21060 (4345798) 4345798..4346190 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
OI124_RS21065 (4346243) 4346243..4346725 + 483 WP_000183494.1 GyrI-like domain-containing protein -
OI124_RS21070 (4346930) 4346930..4347226 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
OI124_RS21075 (4347228) 4347228..4347623 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
OI124_RS21080 (4347756) 4347756..4349363 + 1608 WP_001701096.1 ABC transporter substrate-binding protein -
OI124_RS21085 (4349501) 4349501..4351759 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4335202..4347623 12421


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T262533 WP_000415584.1 NZ_CP109953:4346930-4347226 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT262533 WP_000650107.1 NZ_CP109953:4347228-4347623 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References