Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 746350..747125 Replicon chromosome
Accession NZ_CP109948
Organism Klebsiella pneumoniae strain KP1650

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag OIS41_RS03720 Protein ID WP_004150910.1
Coordinates 746640..747125 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag OIS41_RS03715 Protein ID WP_004150912.1
Coordinates 746350..746643 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIS41_RS03695 (OIS41_03695) 741558..742160 - 603 WP_062954968.1 short chain dehydrogenase -
OIS41_RS03700 (OIS41_03700) 742258..743169 + 912 WP_004188550.1 LysR family transcriptional regulator -
OIS41_RS03705 (OIS41_03705) 743170..744318 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
OIS41_RS03710 (OIS41_03710) 744329..745705 - 1377 WP_004217775.1 cystathionine beta-synthase -
OIS41_RS03715 (OIS41_03715) 746350..746643 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
OIS41_RS03720 (OIS41_03720) 746640..747125 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
OIS41_RS03725 (OIS41_03725) 747829..748422 + 594 WP_004188553.1 hypothetical protein -
OIS41_RS03730 (OIS41_03730) 748519..748735 + 217 Protein_733 transposase -
OIS41_RS03735 (OIS41_03735) 749341..750213 + 873 WP_004188557.1 ParA family protein -
OIS41_RS03740 (OIS41_03740) 750213..750596 + 384 WP_004150906.1 hypothetical protein -
OIS41_RS03745 (OIS41_03745) 750589..751956 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 748519..748671 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T262492 WP_004150910.1 NZ_CP109948:746640-747125 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT262492 WP_004150912.1 NZ_CP109948:746350-746643 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References