Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2108826..2109345 Replicon chromosome
Accession NZ_CP109940
Organism Streptococcus suis strain ID34572

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag OHM49_RS10435 Protein ID WP_013730620.1
Coordinates 2108826..2109083 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag OHM49_RS10440 Protein ID WP_002939010.1
Coordinates 2109085..2109345 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM49_RS10420 (OHM49_10420) 2105297..2107027 - 1731 WP_249547134.1 hypothetical protein -
OHM49_RS10425 (OHM49_10425) 2107390..2108262 - 873 WP_009910907.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
OHM49_RS10430 (OHM49_10430) 2108282..2108812 - 531 WP_009910909.1 DUF1697 domain-containing protein -
OHM49_RS10435 (OHM49_10435) 2108826..2109083 - 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
OHM49_RS10440 (OHM49_10440) 2109085..2109345 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OHM49_RS10445 (OHM49_10445) 2109421..2109876 - 456 WP_013730621.1 8-oxo-dGTP diphosphatase -
OHM49_RS10450 (OHM49_10450) 2109880..2110248 - 369 WP_013730622.1 hypothetical protein -
OHM49_RS10455 (OHM49_10455) 2110241..2110810 - 570 WP_022540720.1 ribonuclease M5 -
OHM49_RS10460 (OHM49_10460) 2110794..2111576 - 783 WP_002939015.1 TatD family hydrolase -
OHM49_RS10465 (OHM49_10465) 2111684..2111821 - 138 WP_002939016.1 50S ribosomal protein L34 -
OHM49_RS10470 (OHM49_10470) 2111989..2112984 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -
OHM49_RS10475 (OHM49_10475) 2113004..2113816 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
OHM49_RS10480 (OHM49_10480) 2113800..2114159 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T262465 WP_013730620.1 NZ_CP109940:c2109083-2108826 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT262465 WP_002939010.1 NZ_CP109940:c2109345-2109085 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References