Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2113182..2113701 Replicon chromosome
Accession NZ_CP109937
Organism Streptococcus suis strain TRG6

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag OHM52_RS10485 Protein ID WP_013730620.1
Coordinates 2113182..2113439 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag OHM52_RS10490 Protein ID WP_002939010.1
Coordinates 2113441..2113701 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM52_RS10470 (OHM52_10470) 2109653..2111383 - 1731 WP_249547134.1 hypothetical protein -
OHM52_RS10475 (OHM52_10475) 2111746..2112618 - 873 WP_009910907.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
OHM52_RS10480 (OHM52_10480) 2112638..2113168 - 531 WP_009910909.1 DUF1697 domain-containing protein -
OHM52_RS10485 (OHM52_10485) 2113182..2113439 - 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
OHM52_RS10490 (OHM52_10490) 2113441..2113701 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OHM52_RS10495 (OHM52_10495) 2113777..2114232 - 456 WP_013730621.1 8-oxo-dGTP diphosphatase -
OHM52_RS10500 (OHM52_10500) 2114236..2114604 - 369 WP_013730622.1 hypothetical protein -
OHM52_RS10505 (OHM52_10505) 2114597..2115166 - 570 WP_022540720.1 ribonuclease M5 -
OHM52_RS10510 (OHM52_10510) 2115150..2115932 - 783 WP_002939015.1 TatD family hydrolase -
OHM52_RS10515 (OHM52_10515) 2116040..2116177 - 138 WP_002939016.1 50S ribosomal protein L34 -
OHM52_RS10520 (OHM52_10520) 2116345..2117340 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -
OHM52_RS10525 (OHM52_10525) 2117360..2118172 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
OHM52_RS10530 (OHM52_10530) 2118156..2118515 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T262456 WP_013730620.1 NZ_CP109937:c2113439-2113182 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT262456 WP_002939010.1 NZ_CP109937:c2113701-2113441 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References