Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2466658..2467175 Replicon chromosome
Accession NZ_CP109933
Organism Staphylococcus aureus strain SASWT1215

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag NT398_RS12260 Protein ID WP_000113265.1
Coordinates 2466909..2467175 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NT398_RS12255 Protein ID WP_000584499.1
Coordinates 2466658..2466909 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NT398_RS12225 (2462356) 2462356..2463075 + 720 WP_000479576.1 amino acid ABC transporter permease -
NT398_RS12230 (2463072) 2463072..2463803 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
NT398_RS12235 (2463900) 2463900..2465150 - 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
NT398_RS12240 (2465405) 2465405..2465767 + 363 WP_000819843.1 DUF4467 domain-containing protein -
NT398_RS12245 (2465786) 2465786..2466385 + 600 WP_000162810.1 DsbA family protein -
NT398_RS12250 (2466413) 2466413..2466493 + 81 WP_223197974.1 hypothetical protein -
NT398_RS12255 (2466658) 2466658..2466909 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NT398_RS12260 (2466909) 2466909..2467175 + 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
NT398_RS12265 (2467210) 2467210..2467281 + 72 Protein_2387 hypothetical protein -
NT398_RS12270 (2467470) 2467470..2469017 + 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NT398_RS12275 (2469203) 2469203..2469670 + 468 WP_000153347.1 SRPBCC domain-containing protein -
NT398_RS12280 (2469754) 2469754..2469936 + 183 WP_000230292.1 hypothetical protein -
NT398_RS12285 (2470153) 2470153..2470977 + 825 WP_000572038.1 formate/nitrite transporter family protein -
NT398_RS12290 (2471211) 2471211..2471747 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T262445 WP_000113265.1 NZ_CP109933:2466909-2467175 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT262445 WP_000584499.1 NZ_CP109933:2466658-2466909 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References