Detailed information of TA system TA262441

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1752810..1753389
• Replicon: chromosome
• Accession: NZ_CP109933
• Organism: Staphylococcus aureus strain SASWT1215

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: NT398_RS08970
• Protein ID: WP_001025401.1
• Coordinates: 1753144..1753389 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1752810..1753175 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NT398_RS08920 (1749090)	1749090..1749647	-	558	WP_000645042.1	DUF2815 family protein	-
NT398_RS08925 (1749673)	1749673..1750839	-	1167	WP_000762547.1	DUF2800 domain-containing protein	-
NT398_RS08930 (1750836)	1750836..1751198	-	363	WP_000985976.1	hypothetical protein	-
NT398_RS08935 (1751213)	1751213..1751536	-	324	WP_000174994.1	hypothetical protein	-
NT398_RS08940 (1751615)	1751615..1751776	-	162	WP_001285963.1	DUF1270 family protein	-
NT398_RS08945 (1751789)	1751789..1752052	-	264	WP_001124159.1	helix-turn-helix domain-containing protein	-
NT398_RS08950 (1752107)	1752107..1752316	+	210	WP_000642492.1	hypothetical protein	-
NT398_RS08955 (1752306)	1752306..1752449	-	144	WP_000939498.1	hypothetical protein	-
NT398_RS08960 (1752540)	1752540..1752755	-	216	WP_001097552.1	hypothetical protein	-
NT398_RS08965 (1752810)	1752810..1753175	+	366	WP_001128433.1	hypothetical protein	Antitoxin
NT398_RS08970 (1753144)	1753144..1753389	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
NT398_RS08975 (1753439)	1753439..1753657	-	219	WP_001001383.1	hypothetical protein	-
NT398_RS08980 (1753673)	1753673..1754449	-	777	WP_061389040.1	phage antirepressor	-
NT398_RS08985 (1754465)	1754465..1754683	-	219	WP_001198673.1	helix-turn-helix transcriptional regulator	-
NT398_RS08990 (1754825)	1754825..1755547	+	723	WP_024936995.1	XRE family transcriptional regulator	-
NT398_RS08995 (1755559)	1755559..1755705	+	147	WP_001049401.1	hypothetical protein	-
NT398_RS09000 (1755702)	1755702..1755887	+	186	WP_024936996.1	hypothetical protein	-
NT398_RS09005 (1755943)	1755943..1756527	+	585	WP_161081411.1	hypothetical protein	-
NT398_RS09010 (1756757)	1756757..1756903	+	147	WP_078367450.1	hypothetical protein	-
NT398_RS09015 (1756900)	1756900..1757514	-	615	WP_031808062.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	geh	1713591..1769400	55809

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T262441 WP_001025401.1 NZ_CP109933:c1753389-1753144 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT262441 NZ_CP109933:1752810-1753175 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTGGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin