Detailed information of TA system TA262434

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 20010..20317
• Replicon: chromosome
• Accession: NZ_CP109933
• Organism: Staphylococcus aureus strain SASWT1215

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: NT398_RS00110
• Protein ID: WP_072482930.1
• Coordinates: 20010..20186 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	20178..20317 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NT398_RS00090 (17840)	17840..17992	+	153	WP_001000058.1	hypothetical protein	-
NT398_RS00095 (18038)	18038..18325	+	288	WP_001262621.1	hypothetical protein	-
NT398_RS00100 (18381)	18381..18755	+	375	WP_000340977.1	hypothetical protein	-
NT398_RS00105 (19128)	19128..19901	+	774	WP_000750412.1	staphylococcal enterotoxin type A	-
NT398_RS00110 (20010)	20010..20186	+	177	WP_072482930.1	type I toxin-antitoxin system toxin PepG1	Toxin
- (20178)	20178..20317	-	140	NuclAT_0	-	Antitoxin
- (20178)	20178..20317	-	140	NuclAT_0	-	Antitoxin
- (20178)	20178..20317	-	140	NuclAT_0	-	Antitoxin
- (20178)	20178..20317	-	140	NuclAT_0	-	Antitoxin
NT398_RS00115 (20239)	20239..20346	-	108	Protein_22	hypothetical protein	-
NT398_RS00120 (20398)	20398..20652	+	255	WP_000611512.1	phage holin	-
NT398_RS00125 (20664)	20664..21419	+	756	WP_000861038.1	CHAP domain-containing protein	-
NT398_RS00130 (21610)	21610..22101	+	492	WP_000920041.1	staphylokinase	-
NT398_RS00135 (22754)	22754..23089	+	336	Protein_26	SH3 domain-containing protein	-
NT398_RS00140 (23599)	23599..23939	+	341	Protein_27	complement inhibitor SCIN-A	-
NT398_RS00145 (23992)	23992..24252	-	261	WP_001791826.1	hypothetical protein	-
NT398_RS00150 (24563)	24563..24742	-	180	WP_000669789.1	hypothetical protein	-
NT398_RS00155 (25114)	25114..25311	-	198	WP_000239610.1	phospholipase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sea / sak / scn / scn	1..23939	23938

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T262434 WP_072482930.1 NZ_CP109933:20010-20186 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT262434 NZ_CP109933:c20317-20178 [Staphylococcus aureus]
ATATATATAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin