Detailed information of TA system TA262432

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 20010..20348
• Replicon: chromosome
• Accession: NZ_CP109933
• Organism: Staphylococcus aureus strain SASWT1215

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: NT398_RS00110
• Protein ID: WP_072482930.1
• Coordinates: 20010..20186 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	20174..20348 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NT398_RS00090	17840..17992	+	153	WP_001000058.1	hypothetical protein	-
NT398_RS00095	18038..18325	+	288	WP_001262621.1	hypothetical protein	-
NT398_RS00100	18381..18755	+	375	WP_000340977.1	hypothetical protein	-
NT398_RS00105	19128..19901	+	774	WP_000750412.1	staphylococcal enterotoxin type A	-
NT398_RS00110	20010..20186	+	177	WP_072482930.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	20174..20348	-	175	-	-	Antitoxin
NT398_RS00120	20398..20652	+	255	WP_000611512.1	phage holin	-
NT398_RS00125	20664..21419	+	756	WP_000861038.1	CHAP domain-containing protein	-
NT398_RS00130	21610..22101	+	492	WP_000920041.1	staphylokinase	-
NT398_RS00135	22754..23089	+	336	Protein_26	SH3 domain-containing protein	-
NT398_RS00140	23599..23939	+	341	Protein_27	complement inhibitor SCIN-A	-
NT398_RS00145	23992..24252	-	261	WP_001791826.1	hypothetical protein	-
NT398_RS00150	24563..24742	-	180	WP_000669789.1	hypothetical protein	-
NT398_RS00155	25114..25311	-	198	WP_000239610.1	phospholipase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sea / sak / scn / scn	1..23939	23938

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T262432 WP_072482930.1 NZ_CP109933:20010-20186 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 175 bp

>AT262432 NZ_CP109933:c20348-20174 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATATAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin