Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1544079..1544674 Replicon chromosome
Accession NZ_CP109931
Organism Pseudomonas aeruginosa strain PALA42

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PALA42_RS07205 Protein ID WP_003117425.1
Coordinates 1544079..1544357 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA42_RS07210 Protein ID WP_003113527.1
Coordinates 1544369..1544674 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA42_RS07185 (PALA42_01422) 1539505..1540743 + 1239 WP_003113524.1 dipeptidase -
PALA42_RS07190 (PALA42_01423) 1540805..1541452 + 648 WP_003095021.1 carbonate dehydratase -
PALA42_RS07195 (PALA42_01424) 1541522..1543750 - 2229 WP_004352671.1 TonB-dependent receptor -
PALA42_RS07200 1543898..1544026 + 129 Protein_1419 integrase -
PALA42_RS07205 1544079..1544357 + 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA42_RS07210 (PALA42_01425) 1544369..1544674 + 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
PALA42_RS07220 (PALA42_01427) 1545081..1546181 - 1101 WP_003099270.1 redox-regulated ATPase YchF -
PALA42_RS07225 (PALA42_01428) 1546222..1546806 - 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PALA42_RS07230 (PALA42_01429) 1546848..1547462 - 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
PALA42_RS07235 (PALA42_01430) 1547579..1548520 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PALA42_RS07245 (PALA42_01432) 1548687..1549535 - 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T262420 WP_003117425.1 NZ_CP109931:1544079-1544357 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT262420 WP_003113527.1 NZ_CP109931:1544369-1544674 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References