Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4959395..4959997 Replicon chromosome
Accession NZ_CP109929
Organism Escherichia coli O6:K2:H1 strain C 691-04A

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag N8A71_RS23675 Protein ID WP_000897302.1
Coordinates 4959686..4959997 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N8A71_RS23670 Protein ID WP_000356397.1
Coordinates 4959395..4959685 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8A71_RS23645 (4955468) 4955468..4956370 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
N8A71_RS23650 (4956367) 4956367..4957002 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
N8A71_RS23655 (4956999) 4956999..4957928 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
N8A71_RS23660 (4958144) 4958144..4958362 - 219 WP_001314326.1 CopG family transcriptional regulator -
N8A71_RS23665 (4958758) 4958758..4959036 - 279 WP_001296612.1 hypothetical protein -
N8A71_RS23670 (4959395) 4959395..4959685 - 291 WP_000356397.1 NadS family protein Antitoxin
N8A71_RS23675 (4959686) 4959686..4959997 - 312 WP_000897302.1 hypothetical protein Toxin
N8A71_RS23680 (4960227) 4960227..4961135 + 909 WP_001305059.1 alpha/beta hydrolase -
N8A71_RS23685 (4961199) 4961199..4962140 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
N8A71_RS23690 (4962185) 4962185..4962622 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
N8A71_RS23695 (4962619) 4962619..4963491 - 873 WP_000920762.1 virulence factor BrkB family protein -
N8A71_RS23700 (4963485) 4963485..4964084 - 600 WP_001443191.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T262415 WP_000897302.1 NZ_CP109929:c4959997-4959686 [Escherichia coli O6:K2:H1]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT262415 WP_000356397.1 NZ_CP109929:c4959685-4959395 [Escherichia coli O6:K2:H1]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References