Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4219541..4219799 Replicon chromosome
Accession NZ_CP109929
Organism Escherichia coli O6:K2:H1 strain C 691-04A

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag N8A71_RS20205 Protein ID WP_000809168.1
Coordinates 4219647..4219799 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4219541..4219598 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8A71_RS20190 4215370..4216629 - 1260 WP_000494928.1 hypothetical protein -
N8A71_RS20195 4216758..4218251 - 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
N8A71_RS20200 4218271..4219032 - 762 WP_001274832.1 outer membrane protein OmpK -
- 4219541..4219598 - 58 - - Antitoxin
N8A71_RS20205 4219647..4219799 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
N8A71_RS20210 4219993..4221105 - 1113 WP_001300563.1 IS4-like element IS421 family transposase -
N8A71_RS20215 4221253..4222383 - 1131 WP_001118465.1 molecular chaperone DnaJ -
N8A71_RS20220 4222472..4224388 - 1917 WP_000516135.1 molecular chaperone DnaK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T262410 WP_000809168.1 NZ_CP109929:4219647-4219799 [Escherichia coli O6:K2:H1]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT262410 NZ_CP109929:c4219598-4219541 [Escherichia coli O6:K2:H1]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References