Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4702040..4702642 Replicon chromosome
Accession NZ_CP109921
Organism Escherichia coli O2:K2:H1 strain C 237-04

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag N7L43_RS22675 Protein ID WP_000897302.1
Coordinates 4702331..4702642 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N7L43_RS22670 Protein ID WP_000356397.1
Coordinates 4702040..4702330 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7L43_RS22645 (4698113) 4698113..4699015 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
N7L43_RS22650 (4699012) 4699012..4699647 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
N7L43_RS22655 (4699644) 4699644..4700573 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
N7L43_RS22660 (4700789) 4700789..4701007 - 219 WP_001314326.1 CopG family transcriptional regulator -
N7L43_RS22665 (4701403) 4701403..4701681 - 279 WP_001296612.1 hypothetical protein -
N7L43_RS22670 (4702040) 4702040..4702330 - 291 WP_000356397.1 NadS family protein Antitoxin
N7L43_RS22675 (4702331) 4702331..4702642 - 312 WP_000897302.1 hypothetical protein Toxin
N7L43_RS22680 (4702872) 4702872..4703780 + 909 WP_001305059.1 alpha/beta hydrolase -
N7L43_RS22685 (4703844) 4703844..4704785 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
N7L43_RS22690 (4704830) 4704830..4705267 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
N7L43_RS22695 (4705264) 4705264..4706136 - 873 WP_000920762.1 virulence factor BrkB family protein -
N7L43_RS22700 (4706130) 4706130..4706729 - 600 WP_001443191.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T262370 WP_000897302.1 NZ_CP109921:c4702642-4702331 [Escherichia coli O2:K2:H1]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT262370 WP_000356397.1 NZ_CP109921:c4702330-4702040 [Escherichia coli O2:K2:H1]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References