Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 4154656..4155068 Replicon chromosome
Accession NZ_CP109921
Organism Escherichia coli O2:K2:H1 strain C 237-04

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag N7L43_RS20175 Protein ID WP_000132630.1
Coordinates 4154727..4155068 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 4154656..4154732 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7L43_RS20165 (4151268) 4151268..4152737 + 1470 WP_001315223.1 type I restriction-modification system subunit M -
N7L43_RS20170 (4152737) 4152737..4154506 + 1770 WP_000110076.1 restriction endonuclease subunit S -
- (4154656) 4154656..4154732 - 77 NuclAT_6 - Antitoxin
- (4154656) 4154656..4154732 - 77 NuclAT_6 - Antitoxin
- (4154656) 4154656..4154732 - 77 NuclAT_6 - Antitoxin
- (4154656) 4154656..4154732 - 77 NuclAT_6 - Antitoxin
- (4154656) 4154656..4154732 - 77 NuclAT_7 - Antitoxin
- (4154656) 4154656..4154732 - 77 NuclAT_7 - Antitoxin
- (4154656) 4154656..4154732 - 77 NuclAT_7 - Antitoxin
- (4154656) 4154656..4154732 - 77 NuclAT_7 - Antitoxin
N7L43_RS20175 (4154727) 4154727..4155068 + 342 WP_000132630.1 endoribonuclease SymE Toxin
N7L43_RS20180 (4155115) 4155115..4156278 - 1164 WP_072202028.1 DUF1524 domain-containing protein -
N7L43_RS20185 (4156326) 4156326..4157208 - 883 Protein_3960 DUF262 domain-containing protein -
N7L43_RS20190 (4157614) 4157614..4158534 - 921 WP_000181195.1 Rpn family recombination-promoting nuclease/putative transposase -
N7L43_RS20195 (4158719) 4158719..4159999 + 1281 WP_001304526.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T262364 WP_000132630.1 NZ_CP109921:4154727-4155068 [Escherichia coli O2:K2:H1]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT262364 NZ_CP109921:c4154732-4154656 [Escherichia coli O2:K2:H1]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References