Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4073441..4073699 Replicon chromosome
Accession NZ_CP109921
Organism Escherichia coli O2:K2:H1 strain C 237-04

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag N7L43_RS19785 Protein ID WP_000809168.1
Coordinates 4073547..4073699 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4073441..4073498 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7L43_RS19770 4069270..4070529 - 1260 WP_171854672.1 cytoplasmic protein -
N7L43_RS19775 4070658..4072151 - 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
N7L43_RS19780 4072171..4072932 - 762 WP_001274832.1 outer membrane protein OmpK -
- 4073441..4073498 - 58 - - Antitoxin
N7L43_RS19785 4073547..4073699 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
N7L43_RS19790 4073804..4074934 - 1131 WP_001118464.1 molecular chaperone DnaJ -
N7L43_RS19795 4075023..4076939 - 1917 WP_000516135.1 molecular chaperone DnaK -
N7L43_RS19800 4077311..4077715 + 405 WP_000843687.1 DUF2541 family protein -
N7L43_RS19805 4077741..4078454 + 714 WP_001102391.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T262363 WP_000809168.1 NZ_CP109921:4073547-4073699 [Escherichia coli O2:K2:H1]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT262363 NZ_CP109921:c4073498-4073441 [Escherichia coli O2:K2:H1]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References