Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2013377..2013879 Replicon chromosome
Accession NZ_CP109921
Organism Escherichia coli O2:K2:H1 strain C 237-04

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag N7L43_RS09660 Protein ID WP_000767832.1
Coordinates 2013625..2013879 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag N7L43_RS09655 Protein ID WP_001259255.1
Coordinates 2013377..2013628 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7L43_RS09630 (2008555) 2008555..2009622 - 1068 WP_032285342.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
N7L43_RS09635 (2009622) 2009622..2010692 - 1071 WP_032285343.1 histidinol-phosphate transaminase -
N7L43_RS09640 (2010689) 2010689..2011993 - 1305 WP_024198577.1 histidinol dehydrogenase -
N7L43_RS09645 (2011999) 2011999..2012898 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
N7L43_RS09650 (2013044) 2013044..2013094 - 51 WP_001364200.1 his operon leader peptide -
N7L43_RS09655 (2013377) 2013377..2013628 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
N7L43_RS09660 (2013625) 2013625..2013879 + 255 WP_000767832.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
N7L43_RS09665 (2013962) 2013962..2014786 + 825 WP_000754737.1 SDR family oxidoreductase -
N7L43_RS09670 (2014832) 2014832..2015761 + 930 WP_032285344.1 LysR substrate-binding domain-containing protein -
N7L43_RS09675 (2015976) 2015976..2016038 + 63 WP_010723108.1 membrane protein YoeI -
N7L43_RS09680 (2016028) 2016028..2017386 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10232.66 Da        Isoelectric Point: 8.0280

>T262355 WP_000767832.1 NZ_CP109921:2013625-2013879 [Escherichia coli O2:K2:H1]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHYLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT262355 WP_001259255.1 NZ_CP109921:2013377-2013628 [Escherichia coli O2:K2:H1]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References