Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 731246..731939 Replicon chromosome
Accession NZ_CP109921
Organism Escherichia coli O2:K2:H1 strain C 237-04

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag N7L43_RS03595 Protein ID WP_000415584.1
Coordinates 731246..731542 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag N7L43_RS03600 Protein ID WP_000650107.1
Coordinates 731544..731939 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7L43_RS03560 (726334) 726334..726648 - 315 WP_000958598.1 putative quinol monooxygenase -
N7L43_RS03565 (726679) 726679..727260 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
N7L43_RS03570 (727579) 727579..727911 + 333 WP_000917684.1 DUF2645 family protein -
N7L43_RS03575 (727957) 727957..729306 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
N7L43_RS03580 (729303) 729303..729962 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
N7L43_RS03585 (730114) 730114..730506 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
N7L43_RS03590 (730559) 730559..731041 + 483 WP_000183505.1 GyrI-like domain-containing protein -
N7L43_RS03595 (731246) 731246..731542 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
N7L43_RS03600 (731544) 731544..731939 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
N7L43_RS03605 (732072) 732072..733679 + 1608 WP_021561146.1 ABC transporter substrate-binding protein -
N7L43_RS03610 (733817) 733817..736075 + 2259 WP_021519502.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T262351 WP_000415584.1 NZ_CP109921:731246-731542 [Escherichia coli O2:K2:H1]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT262351 WP_000650107.1 NZ_CP109921:731544-731939 [Escherichia coli O2:K2:H1]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References