Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5926752..5927347 Replicon chromosome
Accession NZ_CP109920
Organism Pseudomonas aeruginosa strain PALA39

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PALA39_RS28335 Protein ID WP_003117425.1
Coordinates 5927069..5927347 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA39_RS28330 Protein ID WP_003099268.1
Coordinates 5926752..5927057 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA39_RS28300 5922697..5922987 - 291 WP_031640334.1 DUF5447 family protein -
PALA39_RS28305 (PALA39_05596) 5923163..5923435 - 273 WP_004352675.1 hypothetical protein -
PALA39_RS28310 (PALA39_05597) 5923545..5923811 + 267 WP_023088595.1 hypothetical protein -
PALA39_RS28315 5923867..5924202 + 336 WP_031637200.1 hypothetical protein -
PALA39_RS28320 (PALA39_05598) 5924355..5925572 + 1218 WP_071534385.1 AAA family ATPase -
PALA39_RS28325 (PALA39_05599) 5925573..5926301 + 729 WP_124075417.1 hypothetical protein -
PALA39_RS28330 (PALA39_05600) 5926752..5927057 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PALA39_RS28335 5927069..5927347 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA39_RS28340 5927400..5927528 - 129 Protein_5598 integrase -
PALA39_RS28345 (PALA39_05601) 5927676..5929904 + 2229 WP_003099265.1 TonB-dependent receptor -
PALA39_RS28350 (PALA39_05602) 5929974..5930621 - 648 WP_003095021.1 carbonate dehydratase -
PALA39_RS28355 (PALA39_05603) 5930683..5931921 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T262349 WP_003117425.1 NZ_CP109920:c5927347-5927069 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT262349 WP_003099268.1 NZ_CP109920:c5927057-5926752 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References