262341

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5306287..5306882 Replicon chromosome
Accession NZ_CP109919
Organism Pseudomonas aeruginosa strain PALA56

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PALA56_RS24860 Protein ID WP_003117425.1
Coordinates 5306604..5306882 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA56_RS24855 Protein ID WP_003113527.1
Coordinates 5306287..5306592 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA56_RS24820 (PALA56_04931) 5301427..5302275 + 849 WP_003117426.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PALA56_RS24830 (PALA56_04933) 5302442..5303383 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PALA56_RS24835 (PALA56_04934) 5303500..5304114 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
PALA56_RS24840 (PALA56_04935) 5304156..5304740 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PALA56_RS24845 (PALA56_04936) 5304781..5305881 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
PALA56_RS24855 (PALA56_04938) 5306287..5306592 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
PALA56_RS24860 5306604..5306882 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA56_RS24865 5306935..5307063 - 129 Protein_4910 integrase -
PALA56_RS24870 (PALA56_04939) 5307211..5309439 + 2229 WP_003113525.1 TonB-dependent receptor -
PALA56_RS24875 (PALA56_04940) 5309509..5310156 - 648 WP_003095021.1 carbonate dehydratase -
PALA56_RS24880 (PALA56_04941) 5310218..5311456 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T262341 WP_003117425.1 NZ_CP109919:c5306882-5306604 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT262341 WP_003113527.1 NZ_CP109919:c5306592-5306287 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References