Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5437854..5438449 Replicon chromosome
Accession NZ_CP109918
Organism Pseudomonas aeruginosa strain PALA55

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PALA55_RS25315 Protein ID WP_003113526.1
Coordinates 5438171..5438449 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA55_RS25310 Protein ID WP_003099268.1
Coordinates 5437854..5438159 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA55_RS25275 (PALA55_05004) 5432994..5433842 + 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PALA55_RS25285 (PALA55_05006) 5434009..5434950 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PALA55_RS25290 (PALA55_05007) 5435067..5435681 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
PALA55_RS25295 (PALA55_05008) 5435723..5436307 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PALA55_RS25300 (PALA55_05009) 5436348..5437448 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
PALA55_RS25310 (PALA55_05011) 5437854..5438159 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PALA55_RS25315 5438171..5438449 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA55_RS25320 5438502..5438630 - 129 Protein_5000 integrase -
PALA55_RS25325 (PALA55_05012) 5438778..5441006 + 2229 WP_003113525.1 TonB-dependent receptor -
PALA55_RS25330 (PALA55_05013) 5441076..5441723 - 648 WP_003095021.1 carbonate dehydratase -
PALA55_RS25335 (PALA55_05014) 5441785..5443023 - 1239 WP_003111578.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T262335 WP_003113526.1 NZ_CP109918:c5438449-5438171 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT262335 WP_003099268.1 NZ_CP109918:c5438159-5437854 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References