Detailed information of TA system TA026230

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 541570..542154
• Replicon: chromosome
• Accession: NC_017059
• Organism: Rhodospirillum photometricum DSM 122

Toxin (Protein)

• Gene name: higB
• Uniprot ID: H6SNX8
• Locus tag: RSPPHO_RS02370
• Protein ID: WP_014413690.1
• Coordinates: 541570..541851 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: RSPPHO_RS02375
• Protein ID: WP_014413691.1
• Coordinates: 541864..542154 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RSPPHO_RS17415	536696..537778	-	1083	WP_051013579.1	tyrosine-type recombinase/integrase	-
RSPPHO_RS02350	537784..538020	-	237	WP_014413687.1	DNA-binding protein	-
RSPPHO_RS02355	538033..538263	-	231	WP_014413688.1	hypothetical protein	-
RSPPHO_RS02360	538260..540887	-	2628	WP_041796365.1	toprim domain-containing protein	-
RSPPHO_RS02365	540896..541141	-	246	WP_041793810.1	hypothetical protein	-
RSPPHO_RS02370	541570..541851	+	282	WP_014413690.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
RSPPHO_RS02375	541864..542154	+	291	WP_014413691.1	HigA family addiction module antidote protein	Antitoxin
RSPPHO_RS02380	542284..542727	+	444	WP_014413692.1	hypothetical protein	-
RSPPHO_RS19625	542743..543219	+	477	WP_157879053.1	hypothetical protein	-
RSPPHO_RS02390	543241..543495	-	255	WP_041793816.1	ogr/Delta-like zinc finger family protein	-
RSPPHO_RS02395	543492..543791	-	300	WP_041793819.1	helix-turn-helix domain-containing protein	-
RSPPHO_RS02400	543935..544456	+	522	WP_041793824.1	helix-turn-helix domain-containing protein	-
RSPPHO_RS18625	544902..545351	-	450	WP_162138078.1	hypothetical protein	-
RSPPHO_RS20345	545437..545784	+	348	WP_162138079.1	hypothetical protein	-
RSPPHO_RS02410	545892..546320	-	429	WP_041793833.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	512295..573787	61492

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (6-94)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10548.17 Da
• Isoelectric Point: 10.5531

>T26230 WP_014413690.1 NC_017059:541570-541851 [Pararhodospirillum photometricum DSM 122]
MIRSFKGKLARAVWEGQATKGFPADLLHPAQRKLIMLAAAIDLNTLRQPPGNRLEALKGNRKGQHSIRINDQWRICFRWG
DGAAEDVEIVDYH

Nucleotide

• Length: 282 bp

>T26230 NC_017059:541570-541851 [Pararhodospirillum photometricum DSM 122]
ATGATCCGCAGCTTCAAAGGCAAACTGGCTCGGGCGGTGTGGGAAGGCCAGGCCACCAAGGGCTTTCCGGCGGACCTGCT
TCACCCGGCTCAACGCAAACTGATCATGCTTGCGGCGGCCATTGATCTCAACACCTTGCGCCAACCGCCGGGCAATCGCC
TGGAAGCCCTGAAGGGGAACCGGAAGGGACAGCACAGTATTCGCATCAACGATCAGTGGCGCATTTGCTTTCGTTGGGGC
GATGGCGCCGCCGAAGACGTTGAAATCGTCGATTATCACTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10359.03 Da
• Isoelectric Point: 5.0892

>AT26230 WP_014413691.1 NC_017059:541864-542154 [Pararhodospirillum photometricum DSM 122]
MAGPVIHPGEVLREEFLVPLGLSAGAAAKACHVPRTRIERLVAEKTPITADTALRLGRLLGTGPEFWMNMQVLYDLAVAE
RATPDLDDITPVERAA

Nucleotide

• Length: 291 bp

>AT26230 NC_017059:541864-542154 [Pararhodospirillum photometricum DSM 122]
ATGGCCGGTCCCGTTATCCACCCCGGGGAAGTGCTGCGCGAGGAATTCCTGGTCCCCCTGGGCCTGAGTGCTGGCGCTGC
GGCGAAGGCGTGCCATGTGCCACGCACCCGCATTGAGCGGTTGGTCGCGGAAAAGACCCCGATCACGGCCGACACCGCGT
TGCGCCTGGGCCGCCTGCTGGGCACCGGGCCGGAATTCTGGATGAACATGCAGGTGCTTTACGATCTGGCCGTTGCCGAG
CGGGCAACGCCAGACCTTGACGACATCACCCCCGTGGAGCGGGCGGCTTAA

Structures

Toxin

• AlphaFold DB: H6SNX8