262281

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 38919..39565 Replicon plasmid pEC488-4
Accession NZ_CP109878
Organism Escherichia coli strain EC488

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NQ150_RS27270 Protein ID WP_000269912.1
Coordinates 39218..39565 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NQ150_RS27265 Protein ID WP_001673379.1
Coordinates 38919..39218 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ150_RS27230 (NQ150_27230) 34057..34305 + 249 WP_000730008.1 hypothetical protein -
NQ150_RS27235 (NQ150_27235) 35433..35624 + 192 WP_004105259.1 hypothetical protein -
NQ150_RS27240 (NQ150_27240) 35621..36025 + 405 Protein_51 ORF6N domain-containing protein -
NQ150_RS27245 (NQ150_27245) 36194..36820 + 627 WP_235179883.1 Rha family transcriptional regulator -
NQ150_RS27250 (NQ150_27250) 37674..37889 - 216 WP_261630074.1 helix-turn-helix domain-containing protein -
NQ150_RS27255 (NQ150_27255) 37953..38327 - 375 WP_001706261.1 hypothetical protein -
NQ150_RS27260 (NQ150_27260) 38601..38885 + 285 WP_001673380.1 hypothetical protein -
NQ150_RS27265 (NQ150_27265) 38919..39218 - 300 WP_001673379.1 XRE family transcriptional regulator Antitoxin
NQ150_RS27270 (NQ150_27270) 39218..39565 - 348 WP_000269912.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQ150_RS27275 (NQ150_27275) 39810..40073 - 264 WP_000424604.1 hypothetical protein -
NQ150_RS27280 (NQ150_27280) 40097..40384 - 288 WP_000356589.1 hypothetical protein -
NQ150_RS27285 (NQ150_27285) 41028..42005 - 978 WP_001704997.1 plasmid replication initiator RepA -
NQ150_RS27290 (NQ150_27290) 42217..42309 + 93 Protein_61 hypothetical protein -
NQ150_RS27295 (NQ150_27295) 42472..43035 + 564 WP_001523082.1 serine acetyltransferase -
NQ150_RS27300 (NQ150_27300) 42999..43616 - 618 WP_001523080.1 tail fiber assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..49150 49150


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13545.51 Da        Isoelectric Point: 8.8337

>T262281 WP_000269912.1 NZ_CP109878:c39565-39218 [Escherichia coli]
MWTVLFSQRFDDWLNEQEDALQEKVLADLKKLQVYGPELPRPYADTVKGSRYKNMKELRVQFSGRPIRAFYAFDPIRRAI
VLCAGDKSNDKRFYEKLVRIAEDEFAAHLNTLESK

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11069.90 Da        Isoelectric Point: 5.8899

>AT262281 WP_001673379.1 NZ_CP109878:c39218-38919 [Escherichia coli]
MRTLDEVIASRSPESQARIKEMADEMILEVGLQMMREELQLSQKQVAEAMGISQPAVTKLEQRGNDLKLATLKRYVEAMG
GKLSLDVELPTGKRVAFHV

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References