Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4952104..4952706 Replicon chromosome
Accession NZ_CP109874
Organism Escherichia coli strain EC488

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NQ150_RS23940 Protein ID WP_000897305.1
Coordinates 4952395..4952706 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NQ150_RS23935 Protein ID WP_000356397.1
Coordinates 4952104..4952394 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ150_RS23915 (4948606) 4948606..4949508 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NQ150_RS23920 (4949505) 4949505..4950140 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NQ150_RS23925 (4950137) 4950137..4951066 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
NQ150_RS23930 (4951281) 4951281..4951499 - 219 WP_001298592.1 CopG family transcriptional regulator -
NQ150_RS23935 (4952104) 4952104..4952394 - 291 WP_000356397.1 NadS family protein Antitoxin
NQ150_RS23940 (4952395) 4952395..4952706 - 312 WP_000897305.1 hypothetical protein Toxin
NQ150_RS23945 (4952935) 4952935..4953843 + 909 WP_001318161.1 alpha/beta hydrolase -
NQ150_RS23950 (4953907) 4953907..4954848 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NQ150_RS23955 (4954893) 4954893..4955330 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
NQ150_RS23960 (4955327) 4955327..4956199 - 873 WP_000920762.1 virulence factor BrkB family protein -
NQ150_RS23965 (4956193) 4956193..4956792 - 600 WP_001314324.1 glucose-1-phosphatase -
NQ150_RS23970 (4956891) 4956891..4957676 - 786 WP_000059679.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T262266 WP_000897305.1 NZ_CP109874:c4952706-4952395 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT262266 WP_000356397.1 NZ_CP109874:c4952394-4952104 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References