262257

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 4297333..4297745 Replicon chromosome
Accession NZ_CP109874
Organism Escherichia coli strain EC488

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag NQ150_RS20720 Protein ID WP_000132601.1
Coordinates 4297404..4297745 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 4297333..4297409 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ150_RS20710 (4294196) 4294196..4295785 + 1590 WP_001063200.1 type I restriction-modification system methyltransferase -
NQ150_RS20715 (4295782) 4295782..4297176 + 1395 WP_001272445.1 type I restriction-modification system specificity subunit -
- (4297333) 4297333..4297409 - 77 NuclAT_8 - Antitoxin
- (4297333) 4297333..4297409 - 77 NuclAT_8 - Antitoxin
- (4297333) 4297333..4297409 - 77 NuclAT_8 - Antitoxin
- (4297333) 4297333..4297409 - 77 NuclAT_8 - Antitoxin
- (4297333) 4297333..4297409 - 77 NuclAT_9 - Antitoxin
- (4297333) 4297333..4297409 - 77 NuclAT_9 - Antitoxin
- (4297333) 4297333..4297409 - 77 NuclAT_9 - Antitoxin
- (4297333) 4297333..4297409 - 77 NuclAT_9 - Antitoxin
NQ150_RS20720 (4297404) 4297404..4297745 + 342 WP_000132601.1 endoribonuclease SymE Toxin
NQ150_RS20725 (4297907) 4297907..4299286 + 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
NQ150_RS20730 (4299286) 4299286..4300332 + 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T262257 WP_000132601.1 NZ_CP109874:4297404-4297745 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT262257 NZ_CP109874:c4297409-4297333 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References