262241

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 618367..619166 Replicon chromosome
Accession NZ_CP109874
Organism Escherichia coli strain EC488

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag NQ150_RS02970 Protein ID WP_000347273.1
Coordinates 618367..618831 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID D6JF08
Locus tag NQ150_RS02975 Protein ID WP_001308975.1
Coordinates 618831..619166 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ150_RS02940 (613368) 613368..613802 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NQ150_RS02945 (613820) 613820..614698 - 879 WP_001298314.1 PTS N-acetylgalactosamine transporter subunit IID -
NQ150_RS02950 (614688) 614688..615467 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NQ150_RS02955 (615478) 615478..615951 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NQ150_RS02960 (615974) 615974..617254 - 1281 WP_023908831.1 tagatose-bisphosphate aldolase subunit KbaZ -
NQ150_RS02965 (617503) 617503..618312 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NQ150_RS02970 (618367) 618367..618831 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NQ150_RS02975 (618831) 618831..619166 - 336 WP_001308975.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NQ150_RS02980 (619315) 619315..620886 - 1572 WP_023908830.1 galactarate dehydratase -
NQ150_RS02985 (621261) 621261..622595 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
NQ150_RS02990 (622611) 622611..623381 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T262241 WP_000347273.1 NZ_CP109874:c618831-618367 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12343.97 Da        Isoelectric Point: 4.8616

>AT262241 WP_001308975.1 NZ_CP109874:c619166-618831 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB D6JF08

References