Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5268560..5269155 Replicon chromosome
Accession NZ_CP109856
Organism Pseudomonas aeruginosa strain PALA53

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PALA53_RS24385 Protein ID WP_003117425.1
Coordinates 5268877..5269155 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA53_RS24380 Protein ID WP_003113527.1
Coordinates 5268560..5268865 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA53_RS24360 (PALA53_04856) 5264708..5265085 + 378 WP_236080760.1 ATP-binding protein -
PALA53_RS24365 (PALA53_04857) 5265254..5266117 - 864 WP_095396918.1 integrase domain-containing protein -
PALA53_RS24370 (PALA53_04858) 5266719..5267876 - 1158 WP_170949710.1 STY4528 family pathogenicity island replication protein -
PALA53_RS24380 (PALA53_04860) 5268560..5268865 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
PALA53_RS24385 5268877..5269155 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA53_RS24390 5269208..5269336 - 129 Protein_4818 integrase -
PALA53_RS24395 (PALA53_04861) 5269484..5271712 + 2229 WP_095396920.1 TonB-dependent receptor -
PALA53_RS24400 (PALA53_04862) 5271782..5272429 - 648 WP_003095021.1 carbonate dehydratase -
PALA53_RS24405 (PALA53_04863) 5272491..5273729 - 1239 WP_019681675.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T262236 WP_003117425.1 NZ_CP109856:c5269155-5268877 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT262236 WP_003113527.1 NZ_CP109856:c5268865-5268560 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References