Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 640375..641032 Replicon plasmid pESL4.1
Accession NZ_CP109854
Organism Pantoea dispersa strain ESL4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OH655_RS22115 Protein ID WP_181444762.1
Coordinates 640697..641032 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OH655_RS22110 Protein ID WP_104187608.1
Coordinates 640375..640671 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH655_RS22075 (OH655_22075) 635508..635639 + 132 WP_255412114.1 hypothetical protein -
OH655_RS22080 (OH655_22080) 635641..636573 - 933 WP_021508860.1 AraC family transcriptional regulator -
OH655_RS22085 (OH655_22085) 636734..637468 + 735 WP_058758975.1 SDR family oxidoreductase -
OH655_RS22090 (OH655_22090) 637546..638514 - 969 WP_021508858.1 magnesium/cobalt transporter CorA -
OH655_RS22095 (OH655_22095) 638611..638931 - 321 WP_021508856.1 AzlD domain-containing protein -
OH655_RS22100 (OH655_22100) 638921..639595 - 675 WP_021508855.1 AzlC family ABC transporter permease -
OH655_RS22105 (OH655_22105) 639698..640246 + 549 WP_021508854.1 XRE family transcriptional regulator -
OH655_RS22110 (OH655_22110) 640375..640671 - 297 WP_104187608.1 NadS family protein Antitoxin
OH655_RS22115 (OH655_22115) 640697..641032 - 336 WP_181444762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OH655_RS22120 (OH655_22120) 641224..641745 + 522 WP_264444242.1 GNAT family N-acetyltransferase -
OH655_RS22125 (OH655_22125) 641742..643142 - 1401 WP_264444745.1 ATP-binding cassette domain-containing protein -
OH655_RS22130 (OH655_22130) 643142..643918 - 777 WP_215481411.1 ABC transporter permease subunit -
OH655_RS22135 (OH655_22135) 643921..644856 - 936 WP_058758969.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..690879 690879


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(49-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-82)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12827.77 Da        Isoelectric Point: 9.3931

>T262231 WP_181444762.1 NZ_CP109854:c641032-640697 [Pantoea dispersa]
VTGNYLEFIETRVFSKARQSLLADDQEFQELQIFLLEHHELGDTISQTGGCKKIRWSRAGMGKRGGTRIIYYTRLSSGRI
YLLLIYPKNVKDDLNEAEKALLKVFTQQMNL

Download         Length: 336 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11303.11 Da        Isoelectric Point: 6.9894

>AT262231 WP_104187608.1 NZ_CP109854:c640671-640375 [Pantoea dispersa]
MEKQLFNDLLESVQEMVAIEQGHESPDMNRVHRHELPDVKLIRKNAGLKQVEFAHAMGVSVDLIRSWEQHRRNPTGPALK
MLYLIQQQPLLINALQAL

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References