Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 569131..569785 Replicon plasmid pESL4.1
Accession NZ_CP109854
Organism Pantoea dispersa strain ESL4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OH655_RS21715 Protein ID WP_021508927.1
Coordinates 569131..569502 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A246NDM6
Locus tag OH655_RS21720 Protein ID WP_021508926.1
Coordinates 569486..569785 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH655_RS21695 (OH655_21695) 564406..565785 + 1380 WP_264444144.1 heavy metal sensor histidine kinase -
OH655_RS21700 (OH655_21700) 565823..566476 - 654 WP_058770319.1 oxygen-insensitive NAD(P)H nitroreductase -
OH655_RS21705 (OH655_21705) 566581..567582 - 1002 WP_264444146.1 zinc-binding alcohol dehydrogenase family protein -
OH655_RS21710 (OH655_21710) 567719..568636 + 918 WP_058759023.1 LysR family transcriptional regulator -
OH655_RS21715 (OH655_21715) 569131..569502 + 372 WP_021508927.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OH655_RS21720 (OH655_21720) 569486..569785 + 300 WP_021508926.1 XRE family transcriptional regulator Antitoxin
OH655_RS21725 (OH655_21725) 569863..570330 - 468 WP_058759022.1 hypothetical protein -
OH655_RS21730 (OH655_21730) 570516..571445 - 930 WP_059009262.1 ABC transporter substrate-binding protein -
OH655_RS21735 (OH655_21735) 571455..572189 - 735 WP_264444154.1 ABC transporter permease -
OH655_RS21740 (OH655_21740) 572173..572889 - 717 WP_215788040.1 ABC transporter ATP-binding protein -
OH655_RS21745 (OH655_21745) 572886..573854 - 969 WP_021508921.1 HesA/MoeB/ThiF family protein -
OH655_RS21750 (OH655_21750) 573865..574623 - 759 WP_010615680.1 thiazole synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..690879 690879


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(10-88)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14423.65 Da        Isoelectric Point: 10.3873

>T262229 WP_021508927.1 NZ_CP109854:569131-569502 [Pantoea dispersa]
VWQVEATDRFWKWLQAQDEALRLDVLAAMKLLAQYGPHLGRPFVDTLMLSRVPNMKELRVQSKGRPIRSFFVFDPRRHAI
VLCAGNKQGKNQKRFYQQMLRIAETEYHHHLNAIGETHNENLG

Download         Length: 372 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11265.00 Da        Isoelectric Point: 6.7255

>AT262229 WP_021508926.1 NZ_CP109854:569486-569785 [Pantoea dispersa]
MKTLDEMLAALTPEQQHQVDERVSQMRLEYQLYQLREQMQRTQRQQAQAMHIAQSSVAAMEARGAELKISTLKRYIEALG
GELTLGVKMPGGQHVDLII

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A246NDM6

References