Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3152779..3153503 Replicon chromosome
Accession NZ_CP109853
Organism Pantoea dispersa strain ESL4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OH655_RS14755 Protein ID WP_215480918.1
Coordinates 3152779..3153090 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OH655_RS14760 Protein ID WP_021313564.1
Coordinates 3153087..3153503 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH655_RS14740 (OH655_14740) 3148104..3150554 + 2451 WP_021507285.1 acyl-CoA dehydrogenase FadE -
OH655_RS14745 (OH655_14745) 3150739..3151899 + 1161 WP_088517008.1 pyridoxal phosphate-dependent aminotransferase -
OH655_RS14750 (OH655_14750) 3151887..3152657 + 771 WP_264441606.1 amidohydrolase -
OH655_RS14755 (OH655_14755) 3152779..3153090 + 312 WP_215480918.1 type II toxin-antitoxin system HigB family toxin Toxin
OH655_RS14760 (OH655_14760) 3153087..3153503 + 417 WP_021313564.1 transcriptional regulator Antitoxin
OH655_RS14765 (OH655_14765) 3153545..3155743 - 2199 WP_264441607.1 catalase/peroxidase HPI -
OH655_RS14770 (OH655_14770) 3156038..3156373 - 336 WP_021507290.1 hydroxyisourate hydrolase -
OH655_RS14775 (OH655_14775) 3156370..3156864 - 495 WP_264441608.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OH655_RS14780 (OH655_14780) 3156877..3158136 - 1260 WP_132466329.1 allantoate amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12183.06 Da        Isoelectric Point: 10.3546

>T262223 WP_215480918.1 NZ_CP109853:3152779-3153090 [Pantoea dispersa]
MHIISRKVFNEATQRFPNDAAALDATYRLLSGHDFADPQALKAWFPSLDRMKYRAKWWVINVGGNNLRLMFFADFVAKRV
FVKHIVTHAEYDKLVKHYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15331.57 Da        Isoelectric Point: 7.4011

>AT262223 WP_021313564.1 NZ_CP109853:3153087-3153503 [Pantoea dispersa]
MISEAIQASNNLIKAVPLLGGSQSRADYEQALELVEYLVEHQPGHPLIEMLAVKVAKYEETAAEFAAFNARTQALPGGVA
LLRVLMDQHGLNQSSFVAEIGQRSYVNRILKGERRLTDKHKAALARRFNLPFEAFREA

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References