262219

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 168428..169108 Replicon chromosome
Accession NZ_CP109853
Organism Pantoea dispersa strain ESL4

Toxin (Protein)


Gene name higB Uniprot ID A0A246NHY2
Locus tag OH655_RS00755 Protein ID WP_059013049.1
Coordinates 168428..168727 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A246NHX0
Locus tag OH655_RS00760 Protein ID WP_058775157.1
Coordinates 168776..169108 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH655_RS00740 (OH655_00740) 164755..165249 + 495 WP_058775154.1 GNAT family N-acetyltransferase -
OH655_RS00745 (OH655_00745) 165624..166538 - 915 WP_021507882.1 sugar ABC transporter substrate-binding protein -
OH655_RS00750 (OH655_00750) 166974..168368 + 1395 WP_058775155.1 MFS transporter -
OH655_RS00755 (OH655_00755) 168428..168727 + 300 WP_059013049.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OH655_RS00760 (OH655_00760) 168776..169108 + 333 WP_058775157.1 HigA family addiction module antitoxin Antitoxin
OH655_RS00765 (OH655_00765) 169200..170363 + 1164 WP_021507880.1 HD-GYP domain-containing protein -
OH655_RS00770 (OH655_00770) 170472..170561 + 90 WP_021507879.1 K(+)-transporting ATPase subunit F -
OH655_RS00775 (OH655_00775) 170561..172240 + 1680 WP_264441873.1 potassium-transporting ATPase subunit KdpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11503.22 Da        Isoelectric Point: 10.4912

>T262219 WP_059013049.1 NZ_CP109853:168428-168727 [Pantoea dispersa]
MGSIRAFRQAWLAQFYTHGTPHAQIPRAIESALARKLDIIHAATSHQDLRSPPGNRFEALKPPLLGYYSIRVNAQYRLIF
QWAKGEAWDLYLDPHRYKK

Download         Length: 300 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12751.58 Da        Isoelectric Point: 7.2039

>AT262219 WP_058775157.1 NZ_CP109853:168776-169108 [Pantoea dispersa]
MKQAMRKPTSVGDVLQYEFLEPLNLKVNDLAEMLNVHRNTVSALVNNNRKLSTEMAYRLARVFATSIEFWLNLQRHLDQW
EVENDARTQEELSRVMTLSAFLAQRGTQVA

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246NHY2

Antitoxin

Source ID Structure
AlphaFold DB A0A246NHX0

References