Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5398033..5398628 Replicon chromosome
Accession NZ_CP109851
Organism Pseudomonas aeruginosa strain PALA51

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PALA51_RS25505 Protein ID WP_003117425.1
Coordinates 5398350..5398628 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA51_RS25500 Protein ID WP_003113527.1
Coordinates 5398033..5398338 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA51_RS25470 5393638..5393973 + 336 WP_025921265.1 hypothetical protein -
PALA51_RS25475 5393983..5394372 + 390 WP_025921264.1 (deoxy)nucleoside triphosphate pyrophosphohydrolase -
PALA51_RS25480 (PALA51_05051) 5394452..5395183 + 732 WP_079384296.1 HNH endonuclease -
PALA51_RS25485 (PALA51_05052) 5395263..5396246 - 984 WP_079384298.1 anti-phage protein KwaB -
PALA51_RS25490 (PALA51_05053) 5396243..5396833 - 591 WP_079384299.1 anti-phage protein KwaA -
PALA51_RS25495 5397283..5397696 - 414 WP_052150791.1 hypothetical protein -
PALA51_RS25500 (PALA51_05054) 5398033..5398338 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
PALA51_RS25505 5398350..5398628 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA51_RS25510 5398681..5398809 - 129 Protein_5039 integrase -
PALA51_RS25515 (PALA51_05055) 5398957..5401185 + 2229 WP_003113525.1 TonB-dependent receptor -
PALA51_RS25520 (PALA51_05056) 5401255..5401902 - 648 WP_003095021.1 carbonate dehydratase -
PALA51_RS25525 (PALA51_05057) 5401964..5403202 - 1239 WP_003117424.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T262218 WP_003117425.1 NZ_CP109851:c5398628-5398350 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT262218 WP_003113527.1 NZ_CP109851:c5398338-5398033 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References