Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5867515..5868110 Replicon chromosome
Accession NZ_CP109849
Organism Pseudomonas aeruginosa strain PALA34

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PALA34_RS27540 Protein ID WP_003117425.1
Coordinates 5867832..5868110 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA34_RS27535 Protein ID WP_003099268.1
Coordinates 5867515..5867820 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA34_RS27505 (PALA34_05442) 5862968..5863258 - 291 WP_023083237.1 DUF5447 family protein -
PALA34_RS27510 (PALA34_05443) 5863470..5863742 - 273 WP_003115921.1 hypothetical protein -
PALA34_RS27515 (PALA34_05444) 5863852..5864118 + 267 WP_016852153.1 hypothetical protein -
PALA34_RS27520 (PALA34_05445) 5864250..5865086 + 837 WP_223656480.1 helix-turn-helix domain-containing protein -
PALA34_RS27525 (PALA34_05446) 5865061..5866599 + 1539 WP_023082696.1 GNAT family N-acetyltransferase -
PALA34_RS27530 5866611..5867138 - 528 WP_071535723.1 ATP-binding protein -
PALA34_RS27535 (PALA34_05447) 5867515..5867820 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PALA34_RS27540 5867832..5868110 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA34_RS27545 5868163..5868291 - 129 Protein_5446 integrase -
PALA34_RS27550 (PALA34_05448) 5868439..5870667 + 2229 WP_003099265.1 TonB-dependent receptor -
PALA34_RS27555 (PALA34_05449) 5870737..5871384 - 648 WP_003095021.1 carbonate dehydratase -
PALA34_RS27560 (PALA34_05450) 5871446..5872684 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T262204 WP_003117425.1 NZ_CP109849:c5868110-5867832 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT262204 WP_003099268.1 NZ_CP109849:c5867820-5867515 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References