Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5918842..5919437 Replicon chromosome
Accession NZ_CP109845
Organism Pseudomonas aeruginosa strain PALA33

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PALA33_RS28035 Protein ID WP_003113526.1
Coordinates 5919159..5919437 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA33_RS28030 Protein ID WP_003113527.1
Coordinates 5918842..5919147 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA33_RS28010 5914316..5914651 + 336 WP_031633682.1 hypothetical protein -
PALA33_RS28015 (PALA33_05544) 5915183..5916949 - 1767 WP_023087829.1 anti-phage dCTP deaminase -
PALA33_RS28020 (PALA33_05545) 5917206..5917868 - 663 WP_023087830.1 restriction endonuclease -
PALA33_RS28025 5918092..5918505 - 414 WP_049231965.1 hypothetical protein -
PALA33_RS28030 (PALA33_05546) 5918842..5919147 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
PALA33_RS28035 5919159..5919437 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA33_RS28040 5919490..5919618 - 129 Protein_5545 integrase -
PALA33_RS28045 (PALA33_05547) 5919766..5921994 + 2229 WP_003113525.1 TonB-dependent receptor -
PALA33_RS28050 (PALA33_05548) 5922064..5922711 - 648 WP_003095021.1 carbonate dehydratase -
PALA33_RS28055 (PALA33_05549) 5922773..5924011 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T262192 WP_003113526.1 NZ_CP109845:c5919437-5919159 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT262192 WP_003113527.1 NZ_CP109845:c5919147-5918842 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References