262185

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5527268..5527863 Replicon chromosome
Accession NZ_CP109844
Organism Pseudomonas aeruginosa strain PALA32

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PALA32_RS25755 Protein ID WP_003113526.1
Coordinates 5527585..5527863 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA32_RS25750 Protein ID WP_003099268.1
Coordinates 5527268..5527573 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA32_RS25735 (PALA32_05094) 5523998..5524687 - 690 WP_128725157.1 hypothetical protein -
PALA32_RS25740 (PALA32_05095) 5524684..5525961 - 1278 WP_128725156.1 hypothetical protein -
PALA32_RS25745 (PALA32_05096) 5526102..5526761 - 660 WP_128725155.1 hypothetical protein -
PALA32_RS25750 (PALA32_05097) 5527268..5527573 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PALA32_RS25755 5527585..5527863 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA32_RS25760 5527916..5528044 - 129 Protein_5090 integrase -
PALA32_RS25765 (PALA32_05098) 5528192..5530420 + 2229 WP_003099265.1 TonB-dependent receptor -
PALA32_RS25770 (PALA32_05099) 5530490..5531137 - 648 WP_003095021.1 carbonate dehydratase -
PALA32_RS25775 (PALA32_05100) 5531199..5532437 - 1239 WP_019681675.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T262185 WP_003113526.1 NZ_CP109844:c5527863-5527585 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT262185 WP_003099268.1 NZ_CP109844:c5527573-5527268 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References