Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5667837..5668432 Replicon chromosome
Accession NZ_CP109843
Organism Pseudomonas aeruginosa strain PALA29

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PALA29_RS27190 Protein ID WP_003117425.1
Coordinates 5668154..5668432 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA29_RS27185 Protein ID WP_003113527.1
Coordinates 5667837..5668142 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA29_RS27150 (PALA29_05359) 5662976..5663824 + 849 WP_023114865.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PALA29_RS27160 5663991..5664932 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PALA29_RS27165 (PALA29_05361) 5665049..5665663 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
PALA29_RS27170 (PALA29_05362) 5665705..5666289 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PALA29_RS27175 (PALA29_05363) 5666330..5667430 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
PALA29_RS27185 (PALA29_05365) 5667837..5668142 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
PALA29_RS27190 5668154..5668432 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA29_RS27195 5668485..5668613 - 129 Protein_5371 integrase -
PALA29_RS27200 (PALA29_05366) 5668761..5670989 + 2229 WP_003113525.1 TonB-dependent receptor -
PALA29_RS27205 (PALA29_05367) 5671059..5671706 - 648 WP_003095021.1 carbonate dehydratase -
PALA29_RS27210 (PALA29_05368) 5671768..5673006 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T262179 WP_003117425.1 NZ_CP109843:c5668432-5668154 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT262179 WP_003113527.1 NZ_CP109843:c5668142-5667837 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References