Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5672250..5672845 Replicon chromosome
Accession NZ_CP109835
Organism Pseudomonas aeruginosa strain PALA26

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PALA26_RS26540 Protein ID WP_003113526.1
Coordinates 5672567..5672845 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA26_RS26535 Protein ID WP_003133769.1
Coordinates 5672250..5672555 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA26_RS26500 (PALA26_05241) 5667391..5668239 + 849 WP_003095007.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PALA26_RS26510 (PALA26_05243) 5668406..5669347 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PALA26_RS26515 (PALA26_05244) 5669464..5670078 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
PALA26_RS26520 (PALA26_05245) 5670120..5670704 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PALA26_RS26525 (PALA26_05246) 5670745..5671845 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
PALA26_RS26535 (PALA26_05248) 5672250..5672555 - 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
PALA26_RS26540 5672567..5672845 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA26_RS26545 5672898..5673026 - 129 Protein_5244 integrase -
PALA26_RS26550 (PALA26_05249) 5673174..5675402 + 2229 WP_003141628.1 TonB-dependent receptor -
PALA26_RS26555 (PALA26_05250) 5675472..5676119 - 648 WP_003095021.1 carbonate dehydratase -
PALA26_RS26560 (PALA26_05251) 5676181..5677419 - 1239 WP_003141631.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T262165 WP_003113526.1 NZ_CP109835:c5672845-5672567 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT262165 WP_003133769.1 NZ_CP109835:c5672555-5672250 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References