262158

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5265397..5265992 Replicon chromosome
Accession NZ_CP109834
Organism Pseudomonas aeruginosa strain PALA25

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag PALA25_RS24395 Protein ID WP_003117425.1
Coordinates 5265714..5265992 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA25_RS24390 Protein ID WP_003113527.1
Coordinates 5265397..5265702 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA25_RS24370 (PALA25_04861) 5261545..5261922 + 378 WP_236080760.1 ATP-binding protein -
PALA25_RS24375 (PALA25_04862) 5262091..5262954 - 864 WP_095396918.1 integrase domain-containing protein -
PALA25_RS24380 (PALA25_04863) 5263556..5264713 - 1158 WP_170949710.1 STY4528 family pathogenicity island replication protein -
PALA25_RS24390 (PALA25_04865) 5265397..5265702 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
PALA25_RS24395 5265714..5265992 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA25_RS24400 5266045..5266173 - 129 Protein_4818 integrase -
PALA25_RS24405 (PALA25_04866) 5266321..5268549 + 2229 WP_095396920.1 TonB-dependent receptor -
PALA25_RS24410 (PALA25_04867) 5268619..5269266 - 648 WP_003095021.1 carbonate dehydratase -
PALA25_RS24415 (PALA25_04868) 5269328..5270566 - 1239 WP_019681675.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T262158 WP_003117425.1 NZ_CP109834:c5265992-5265714 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT262158 WP_003113527.1 NZ_CP109834:c5265702-5265397 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References