262153

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5343882..5344477 Replicon chromosome
Accession NZ_CP109833
Organism Pseudomonas aeruginosa strain PALA23

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PALA23_RS24790 Protein ID WP_003113526.1
Coordinates 5344199..5344477 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PALA23_RS24785 Protein ID WP_003133769.1
Coordinates 5343882..5344187 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA23_RS24755 5339252..5339524 + 273 WP_071538125.1 DNA-binding protein -
PALA23_RS24760 5339582..5340163 + 582 WP_123903235.1 sce7726 family protein -
PALA23_RS24765 (PALA23_04917) 5340150..5341220 - 1071 WP_023098928.1 beta family protein -
PALA23_RS24770 (PALA23_04918) 5341210..5342046 - 837 WP_079387117.1 ImmA/IrrE family metallo-endopeptidase -
PALA23_RS24775 (PALA23_04919) 5342039..5342713 - 675 WP_023098926.1 N-acetyltransferase -
PALA23_RS24780 5343139..5343546 - 408 WP_049267485.1 hypothetical protein -
PALA23_RS24785 (PALA23_04920) 5343882..5344187 - 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
PALA23_RS24790 5344199..5344477 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA23_RS24795 5344530..5344658 - 129 Protein_4897 integrase -
PALA23_RS24800 (PALA23_04921) 5344806..5347034 + 2229 WP_043089846.1 TonB-dependent receptor -
PALA23_RS24805 (PALA23_04922) 5347104..5347751 - 648 WP_003095021.1 carbonate dehydratase -
PALA23_RS24810 (PALA23_04923) 5347813..5349051 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10614.13 Da        Isoelectric Point: 7.8937

>T262153 WP_003113526.1 NZ_CP109833:c5344477-5344199 [Pseudomonas aeruginosa]
VILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT262153 WP_003133769.1 NZ_CP109833:c5344187-5343882 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References