Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4246359..4247011 Replicon chromosome
Accession NZ_CP109824
Organism Serratia marcescens strain SMBC31

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OHY99_RS20590 Protein ID WP_049206122.1
Coordinates 4246359..4246703 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OHY99_RS20595 Protein ID WP_025304078.1
Coordinates 4246709..4247011 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHY99_RS20580 (OHY99_20585) 4242702..4244960 - 2259 WP_261456825.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
OHY99_RS20585 (OHY99_20590) 4245181..4246200 + 1020 WP_028127674.1 HTH-type transcriptional regulator GalR -
OHY99_RS20590 (OHY99_20595) 4246359..4246703 + 345 WP_049206122.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OHY99_RS20595 (OHY99_20600) 4246709..4247011 + 303 WP_025304078.1 helix-turn-helix transcriptional regulator Antitoxin
OHY99_RS20600 (OHY99_20605) 4247039..4248301 - 1263 WP_089196221.1 diaminopimelate decarboxylase -
OHY99_RS20605 (OHY99_20610) 4248435..4249358 + 924 WP_043139803.1 LysR family transcriptional regulator -
OHY99_RS20610 (OHY99_20615) 4249386..4250294 - 909 WP_049296173.1 LysR family transcriptional regulator -
OHY99_RS20615 (OHY99_20620) 4250403..4251287 + 885 WP_025304082.1 MBL fold metallo-hydrolase -
OHY99_RS20620 (OHY99_20625) 4251356..4252003 + 648 WP_043139796.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(29-89)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13283.28 Da        Isoelectric Point: 10.8296

>T262141 WP_049206122.1 NZ_CP109824:4246359-4246703 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLARPHADTLHFSDAARQLKELRVQHRGRPFRGFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11081.01 Da        Isoelectric Point: 10.3986

>AT262141 WP_025304078.1 NZ_CP109824:4246709-4247011 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References