Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3462265..3462925 Replicon chromosome
Accession NZ_CP109824
Organism Serratia marcescens strain SMBC31

Toxin (Protein)


Gene name higB Uniprot ID A0A656VMD8
Locus tag OHY99_RS16790 Protein ID WP_025303493.1
Coordinates 3462572..3462925 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8G2G5Z5
Locus tag OHY99_RS16785 Protein ID WP_016927038.1
Coordinates 3462265..3462567 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHY99_RS16765 (OHY99_16765) 3457742..3458656 - 915 WP_004928592.1 branched-chain amino acid ABC transporter permease -
OHY99_RS16770 (OHY99_16770) 3458782..3459900 - 1119 WP_016927040.1 branched-chain amino acid ABC transporter substrate-binding protein -
OHY99_RS16780 (OHY99_16780) 3460632..3461840 - 1209 WP_213928418.1 aldose 1-epimerase family protein -
OHY99_RS16785 (OHY99_16785) 3462265..3462567 - 303 WP_016927038.1 XRE family transcriptional regulator Antitoxin
OHY99_RS16790 (OHY99_16790) 3462572..3462925 - 354 WP_025303493.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OHY99_RS16795 (OHY99_16795) 3463364..3464659 + 1296 WP_025303494.1 MFS transporter -
OHY99_RS16800 (OHY99_16800) 3464686..3465492 + 807 WP_213928417.1 substrate-binding domain-containing protein -
OHY99_RS16805 (OHY99_16805) 3465467..3466366 - 900 WP_197822133.1 LysR family transcriptional regulator -
OHY99_RS16810 (OHY99_16810) 3466470..3466835 - 366 WP_004935528.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13548.47 Da        Isoelectric Point: 9.0170

>T262138 WP_025303493.1 NZ_CP109824:c3462925-3462572 [Serratia marcescens]
VWEIKTTDAFDHWYRSLSDADRAGVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQCRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMIQVADREFTNWLNTLNEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.96 Da        Isoelectric Point: 6.4738

>AT262138 WP_016927038.1 NZ_CP109824:c3462567-3462265 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDIELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656VMD8

Antitoxin

Source ID Structure

References