Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3520163..3520704 Replicon chromosome
Accession NZ_CP109775
Organism Shigella sonnei strain CIP_106347

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag OHN14_RS18055 Protein ID WP_000615976.1
Coordinates 3520426..3520704 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag OHN14_RS18050 Protein ID WP_000729704.1
Coordinates 3520163..3520423 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHN14_RS18025 (3515632) 3515632..3517344 + 1713 Protein_3526 flagellar biosynthesis protein FlhA -
OHN14_RS18030 (3517467) 3517467..3517964 - 498 WP_000006258.1 REP-associated tyrosine transposase RayT -
OHN14_RS18035 (3518035) 3518035..3518163 - 129 Protein_3528 ISAs1 family transposase -
OHN14_RS18040 (3518218) 3518218..3518915 + 698 WP_094096600.1 IS1-like element IS1A family transposase -
OHN14_RS18045 (3519204) 3519204..3519977 - 774 WP_127148796.1 C40 family peptidase -
OHN14_RS18050 (3520163) 3520163..3520423 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
OHN14_RS18055 (3520426) 3520426..3520704 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
OHN14_RS18060 (3520860) 3520860..3521600 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
OHN14_RS18065 (3521571) 3521571..3522338 - 768 WP_000333380.1 class II glutamine amidotransferase -
OHN14_RS18070 (3522544) 3522544..3523122 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T262109 WP_000615976.1 NZ_CP109775:3520426-3520704 [Shigella sonnei]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT262109 WP_000729704.1 NZ_CP109775:3520163-3520423 [Shigella sonnei]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References