262101

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1636599..1637101 Replicon chromosome
Accession NZ_CP109775
Organism Shigella sonnei strain CIP_106347

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag OHN14_RS08255 Protein ID WP_000767829.1
Coordinates 1636847..1637101 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag OHN14_RS08250 Protein ID WP_001259255.1
Coordinates 1636599..1636850 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHN14_RS08225 (1631777) 1631777..1632844 - 1068 WP_000080086.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
OHN14_RS08230 (1632844) 1632844..1633914 - 1071 WP_000108977.1 histidinol-phosphate transaminase -
OHN14_RS08235 (1633911) 1633911..1635215 - 1305 WP_001462576.1 histidinol dehydrogenase -
OHN14_RS08240 (1635221) 1635221..1636120 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
OHN14_RS08245 (1636266) 1636266..1636316 - 51 WP_001364200.1 his operon leader peptide -
OHN14_RS08250 (1636599) 1636599..1636850 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
OHN14_RS08255 (1636847) 1636847..1637101 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
OHN14_RS08260 (1637184) 1637184..1638008 + 825 WP_000754737.1 SDR family oxidoreductase -
OHN14_RS08265 (1638054) 1638054..1638983 + 930 WP_000811606.1 LysR substrate-binding domain-containing protein -
OHN14_RS08270 (1639198) 1639198..1639260 + 63 WP_010723108.1 membrane protein YoeI -
OHN14_RS08275 (1639250) 1639250..1640608 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
OHN14_RS08280 (1640787) 1640787..1641845 + 1059 WP_000492295.1 thiosulfate utilization transporter TsuA/YeeE -
OHN14_RS08285 (1641859) 1641859..1642086 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T262101 WP_000767829.1 NZ_CP109775:1636847-1637101 [Shigella sonnei]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT262101 WP_001259255.1 NZ_CP109775:1636599-1636850 [Shigella sonnei]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References