Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 544411..545138 Replicon chromosome
Accession NZ_CP109775
Organism Shigella sonnei strain CIP_106347

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag OHN14_RS02820 Protein ID WP_000550189.1
Coordinates 544824..545138 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OHN14_RS02815 Protein ID WP_000560263.1
Coordinates 544411..544827 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHN14_RS02805 (539771) 539771..542122 + 2352 WP_000695471.1 alpha-glucosidase -
OHN14_RS02810 (542348) 542348..544366 + 2019 WP_000121451.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
OHN14_RS02815 (544411) 544411..544827 - 417 WP_000560263.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
OHN14_RS02820 (544824) 544824..545138 - 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
OHN14_RS02825 (545423) 545423..546559 - 1137 WP_000018685.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
OHN14_RS02830 (546644) 546644..547147 + 504 WP_001305117.1 M48 family metallopeptidase -
OHN14_RS02835 (547224) 547224..547907 + 684 WP_001183060.1 vancomycin high temperature exclusion protein -
OHN14_RS02840 (547986) 547986..548972 + 987 WP_001446103.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T262097 WP_000550189.1 NZ_CP109775:c545138-544824 [Shigella sonnei]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14979.42 Da        Isoelectric Point: 4.4547

>AT262097 WP_000560263.1 NZ_CP109775:c544827-544411 [Shigella sonnei]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLADLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References