Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3886953..3887550 Replicon chromosome
Accession NZ_CP109772
Organism Klebsiella pneumoniae strain YZ-58

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag M4Z05_RS19455 Protein ID WP_004142563.1
Coordinates 3887233..3887550 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag M4Z05_RS19450 Protein ID WP_004142561.1
Coordinates 3886953..3887240 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4Z05_RS19420 (M4Z05_19425) 3883033..3883281 + 249 WP_020325243.1 DUF1158 domain-containing protein -
M4Z05_RS19425 (M4Z05_19430) 3883299..3883640 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
M4Z05_RS19430 (M4Z05_19435) 3883671..3884786 - 1116 WP_020325248.1 MBL fold metallo-hydrolase -
M4Z05_RS19435 (M4Z05_19440) 3884966..3885547 + 582 WP_020325240.1 TetR/AcrR family transcriptional regulator -
M4Z05_RS19440 (M4Z05_19445) 3885547..3885915 + 369 WP_020325252.1 MmcQ/YjbR family DNA-binding protein -
M4Z05_RS19445 (M4Z05_19450) 3886035..3886688 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
M4Z05_RS19450 (M4Z05_19455) 3886953..3887240 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
M4Z05_RS19455 (M4Z05_19460) 3887233..3887550 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M4Z05_RS19460 (M4Z05_19465) 3887735..3888778 - 1044 WP_020802450.1 DUF2157 domain-containing protein -
M4Z05_RS19465 (M4Z05_19470) 3889448..3890314 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
M4Z05_RS19470 (M4Z05_19475) 3890423..3891850 + 1428 WP_009308097.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T262090 WP_004142563.1 NZ_CP109772:c3887550-3887233 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT262090 WP_004142561.1 NZ_CP109772:c3887240-3886953 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References