Detailed information of TA system TA026209

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2751050..2751735
• Replicon: chromosome
• Accession: NC_017047
• Organism: Rahnella aquatilis HX2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: H8NS19
• Locus tag: Q7S_RS12285
• Protein ID: WP_013575753.1
• Coordinates: 2751050..2751364 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: Q7S_RS12290
• Protein ID: WP_015690029.1
• Coordinates: 2751418..2751735 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Q7S_RS12275	2747892..2748911	+	1020	WP_013575750.1	transporter	-
Q7S_RS12280	2748933..2750636	-	1704	WP_013575751.1	chloride channel protein	-
Q7S_RS26685	2750643..2750876	-	234	WP_013575752.1	hypothetical protein	-
Q7S_RS12285	2751050..2751364	+	315	WP_013575753.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Q7S_RS12290	2751418..2751735	+	318	WP_015690029.1	HigA family addiction module antidote protein	Antitoxin
Q7S_RS12295	2751850..2753427	-	1578	WP_015690030.1	ABC transporter substrate-binding protein	-
Q7S_RS12300	2753570..2754247	-	678	WP_015690031.1	ATP-binding cassette domain-containing protein	-
Q7S_RS12305	2754240..2755124	-	885	WP_013575757.1	ABC transporter ATP-binding protein	-
Q7S_RS12310	2755114..2755992	-	879	WP_013575758.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (6-100)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-70)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12595.39 Da
• Isoelectric Point: 9.2702

>T26209 WP_013575753.1 NC_017047:2751050-2751364 [Rahnella aquatilis HX2]
MNDMLRISSFRDQWLEDFFHFATPHRKIPWTLATALERKLDMINAAMDYRDLLWPPGNRYEDLAPPLKGFSSIRVNEQYR
LIFYWREGKAHGLYLDPHGYRSYR

Nucleotide

• Length: 315 bp

>T26209 NC_017047:2751050-2751364 [Rahnella aquatilis HX2]
ATGAACGATATGCTCAGGATAAGCAGTTTCCGCGATCAATGGCTGGAAGACTTTTTCCACTTCGCCACTCCCCATCGCAA
AATACCCTGGACGCTGGCAACTGCTCTGGAAAGGAAGCTGGATATGATCAATGCCGCAATGGATTATCGCGATTTACTCT
GGCCCCCGGGCAATCGCTATGAAGATCTGGCCCCCCCGTTAAAGGGATTTTCATCGATCAGGGTGAATGAGCAGTACCGT
CTGATTTTTTACTGGCGGGAAGGAAAAGCACATGGCCTGTATTTAGATCCCCACGGTTACAGGAGTTACCGGTAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 12115.02 Da
• Isoelectric Point: 8.6390

>AT26209 WP_015690029.1 NC_017047:2751418-2751735 [Rahnella aquatilis HX2]
MAVTTRKPATVGDILLYEFLEPAGLRINDLADMLNVHRNTISALVNNNRKLTVDIAFRLAKTFETSVEFWLNLQTNVDIW
EVRNNPRLMDDINKVAHLKDFMKKS

Nucleotide

• Length: 318 bp

>AT26209 NC_017047:2751418-2751735 [Rahnella aquatilis HX2]
ATGGCTGTGACCACACGTAAACCCGCTACCGTTGGTGATATTTTACTTTACGAATTTCTCGAGCCTGCAGGCCTGCGGAT
CAACGATCTCGCCGACATGCTGAATGTTCACCGCAATACCATCAGCGCGCTGGTGAATAACAACCGCAAACTGACCGTTG
ATATTGCCTTCCGGCTGGCAAAGACATTTGAGACCTCTGTCGAGTTTTGGTTAAACCTGCAAACCAATGTCGATATTTGG
GAAGTGCGCAATAACCCGCGCCTGATGGATGACATTAACAAAGTCGCCCATCTGAAAGATTTTATGAAAAAGTCATGA

Structures

Toxin

• AlphaFold DB: H8NS19