Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2471874..2472523 Replicon chromosome
Accession NZ_CP109753
Organism Enterobacter roggenkampii strain 2017-45-131-01A

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OI984_RS12110 Protein ID WP_045352827.1
Coordinates 2471874..2472227 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1H8WUL1
Locus tag OI984_RS12115 Protein ID WP_045352829.1
Coordinates 2472224..2472523 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI984_RS12085 (OI984_12085) 2468292..2469104 + 813 WP_045352820.1 hypothetical protein -
OI984_RS12090 (OI984_12090) 2469601..2469771 - 171 WP_164725120.1 hypothetical protein -
OI984_RS12095 (OI984_12095) 2469951..2470808 + 858 WP_045352822.1 WYL domain-containing protein -
OI984_RS12100 (OI984_12100) 2470821..2471018 - 198 WP_045352823.1 toxin-antitoxin system HicB family antitoxin -
OI984_RS12105 (OI984_12105) 2471102..2471443 + 342 WP_045352825.1 SymE family type I addiction module toxin -
OI984_RS12110 (OI984_12110) 2471874..2472227 + 354 WP_045352827.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OI984_RS12115 (OI984_12115) 2472224..2472523 + 300 WP_045352829.1 helix-turn-helix transcriptional regulator Antitoxin
OI984_RS12120 (OI984_12120) 2472553..2472990 - 438 WP_045352830.1 acetyltransferase -
OI984_RS12125 (OI984_12125) 2473057..2474103 - 1047 WP_045352831.1 class I SAM-dependent methyltransferase -
OI984_RS12130 (OI984_12130) 2474182..2474706 - 525 WP_008500115.1 lipocalin family protein -
OI984_RS12135 (OI984_12135) 2474824..2475549 + 726 WP_008500116.1 MerR family transcriptional regulator -
OI984_RS12140 (OI984_12140) 2475649..2476059 + 411 WP_008500117.1 hydroxyisourate hydrolase -
OI984_RS12145 (OI984_12145) 2476162..2477121 + 960 WP_032675710.1 DUF523 and DUF1722 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(42-80)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13508.45 Da        Isoelectric Point: 8.8479

>T262069 WP_045352827.1 NZ_CP109753:2471874-2472227 [Enterobacter roggenkampii]
VDGSVRFGKVFEQWLFEQEEGLQDKVLADLLNLQHYGPRLPRPYADTVKGSRYKHMKELRIQYAGRPVRAFFAFDPVRQA
IVLCAGDKSNDKTFYEKMIRIADAEFSLHLTSQEAAK

Download         Length: 354 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11146.05 Da        Isoelectric Point: 8.0121

>AT262069 WP_045352829.1 NZ_CP109753:2472224-2472523 [Enterobacter roggenkampii]
VKTLNEVIASRSPESQQRIKEMAEEMILETGLQLLREELRLSQKKVADLMGVSQPAVTQIEQRGNELKIATLKRYIEAMG
GKLCIDVELPTGKRVAFHI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1H8WUL1

References