Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3811188..3811750 Replicon chromosome
Accession NZ_CP109744
Organism Citrobacter portucalensis strain 2017-45-163

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OI981_RS18325 Protein ID WP_060683726.1
Coordinates 3811472..3811750 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6H3AUF8
Locus tag OI981_RS18320 Protein ID WP_003833018.1
Coordinates 3811188..3811472 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI981_RS18305 (OI981_18295) 3808883..3809767 + 885 WP_003833024.1 formate dehydrogenase N subunit beta -
OI981_RS18310 (OI981_18300) 3809760..3810416 + 657 WP_003020054.1 formate dehydrogenase-N subunit gamma -
OI981_RS18315 (OI981_18305) 3810546..3811148 + 603 WP_060682194.1 inorganic diphosphatase -
OI981_RS18320 (OI981_18310) 3811188..3811472 - 285 WP_003833018.1 HigA family addiction module antitoxin Antitoxin
OI981_RS18325 (OI981_18315) 3811472..3811750 - 279 WP_060683726.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OI981_RS18330 (OI981_18320) 3811971..3813686 - 1716 WP_192464120.1 ABC-F family ATP-binding cassette domain-containing protein -
OI981_RS18335 (OI981_18325) 3813996..3815693 - 1698 WP_043016305.1 malate dehydrogenase -
OI981_RS18340 (OI981_18330) 3815873..3816013 - 141 WP_003833009.1 stationary-phase-induced ribosome-associated protein -
OI981_RS18345 (OI981_18335) 3816241..3816672 + 432 WP_003833007.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10649.27 Da        Isoelectric Point: 9.8965

>T262058 WP_060683726.1 NZ_CP109744:c3811750-3811472 [Citrobacter portucalensis]
MIMNFRHKGLRDLFLHGRTSGVIAKHVRRLRHRLAVIDAASKVTDINMPGYKLHPLVGERDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10371.10 Da        Isoelectric Point: 8.8094

>AT262058 WP_003833018.1 NZ_CP109744:c3811472-3811188 [Citrobacter portucalensis]
MKMANHPRPGDIIQEALEELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQNTWSLAEAQ
KSVDISRLRKLAVQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AUF8

References