Detailed information of TA system TA026205

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 87196..88023
• Replicon: chromosome
• Accession: NC_017047
• Organism: Rahnella aquatilis HX2

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: H8NM45
• Locus tag: Q7S_RS00410
• Protein ID: WP_014411451.1
• Coordinates: 87196..87672 (-)
• Length: 159 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: H8NM46
• Locus tag: Q7S_RS00415
• Protein ID: WP_014411452.1
• Coordinates: 87679..88023 (-)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Q7S_RS00385	82435..83880	+	1446	WP_014411450.1	alpha/beta hydrolase	-
Q7S_RS00390	83951..84409	+	459	WP_013573431.1	MarR family transcriptional regulator	-
Q7S_RS00395	84544..84966	+	423	WP_013573432.1	organic hydroperoxide resistance protein	-
Q7S_RS00400	85238..86917	+	1680	WP_013573433.1	kdo(2)-lipid A phosphoethanolamine 7''-transferase	-
Q7S_RS00410	87196..87672	-	477	WP_014411451.1	type II toxin-antitoxin system YhaV family toxin	Toxin
Q7S_RS00415	87679..88023	-	345	WP_014411452.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
Q7S_RS00420	88105..88323	-	219	WP_041672954.1	type II toxin-antitoxin system RelE/ParE family toxin	-
Q7S_RS00425	88406..89785	-	1380	WP_014411454.1	MmgE/PrpD family protein	-
Q7S_RS00430	89805..90587	-	783	WP_014411455.1	ABC transporter ATP-binding protein	-
Q7S_RS00435	90587..91453	-	867	WP_014411456.1	ABC transporter ATP-binding protein	-
Q7S_RS00440	91446..92381	-	936	WP_013573439.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (13-148)

Antitoxin

• PrlF antitoxin (14-112)

Sequences

Toxin

Protein

• Length: 159 a.a.
• Molecular weight: 18482.31 Da
• Isoelectric Point: 9.9550

>T26205 WP_014411451.1 NC_017047:c87672-87196 [Rahnella aquatilis HX2]
MHNQAMEINGWTLLAHPLILQQIQALTDQVVLLRRKDPAGYKSKNATKRLAAINKLMFDVIPQDPARVEFRQGDTLGGEF
SHWFRAKFFQQYRLFFRYNLKSRIIIYAWVNDDKELRAYESKTDAYRMFRKMLKSGEPPDNWQALCEASGKVAAEELP

Nucleotide

• Length: 477 bp

>T26205 NC_017047:c87672-87196 [Rahnella aquatilis HX2]
ATGCACAATCAGGCCATGGAGATTAACGGATGGACCCTTCTCGCTCATCCTCTGATCCTGCAACAAATACAGGCACTCAC
TGATCAGGTTGTTTTACTGCGCCGCAAAGATCCGGCGGGCTATAAAAGTAAAAATGCCACCAAACGGCTGGCTGCGATCA
ATAAGCTGATGTTTGACGTTATCCCGCAGGATCCGGCGCGTGTTGAATTCCGTCAGGGCGATACGTTAGGCGGGGAATTC
TCACACTGGTTCAGGGCAAAATTCTTCCAGCAGTACCGTTTGTTTTTCCGCTACAACCTGAAAAGCCGGATCATTATTTA
CGCCTGGGTGAATGATGATAAAGAATTACGCGCCTACGAAAGCAAAACAGACGCATACCGGATGTTTCGCAAGATGTTGA
AAAGCGGTGAACCGCCAGACAACTGGCAGGCACTTTGCGAGGCGTCAGGGAAGGTAGCGGCGGAAGAATTACCTTAG

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 12731.50 Da
• Isoelectric Point: 4.3324

>AT26205 WP_014411452.1 NC_017047:c88023-87679 [Rahnella aquatilis HX2]
MSASALWGIKFEAESKVTRRFQTTIPTTIRKALNLTENDRIQYKILPDGQVVISRQLEEAEDPVISAFLGFVAKDMLNNP
ENMQPVTLSLHEKINVLTAGMAIDLESPLSDDDE

Nucleotide

• Length: 345 bp

>AT26205 NC_017047:c88023-87679 [Rahnella aquatilis HX2]
ATGTCAGCCTCGGCACTATGGGGAATAAAATTCGAAGCCGAATCCAAAGTCACCCGCCGCTTCCAGACCACCATTCCGAC
CACTATCCGTAAGGCATTAAATCTCACCGAAAATGATCGGATCCAGTACAAGATTTTGCCAGACGGGCAGGTGGTTATTT
CGAGGCAACTCGAAGAAGCGGAAGACCCTGTTATCAGTGCTTTTCTCGGTTTTGTGGCAAAAGATATGCTCAATAACCCG
GAAAATATGCAGCCGGTAACATTATCCCTGCATGAAAAAATCAATGTACTGACCGCCGGGATGGCTATCGATCTTGAGAG
CCCGCTTTCTGACGATGACGAGTAA

Structures

Toxin

• AlphaFold DB: H8NM45

Antitoxin

• AlphaFold DB: H8NM46