Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 653650..654299 Replicon chromosome
Accession NZ_CP109727
Organism Enterobacter roggenkampii strain 2017-45-51-04-01

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OI980_RS03095 Protein ID WP_045352827.1
Coordinates 653946..654299 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1H8WUL1
Locus tag OI980_RS03090 Protein ID WP_045352829.1
Coordinates 653650..653949 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI980_RS03060 (OI980_03060) 649052..650011 - 960 WP_032675710.1 DUF523 and DUF1722 domain-containing protein -
OI980_RS03065 (OI980_03065) 650114..650524 - 411 WP_008500117.1 hydroxyisourate hydrolase -
OI980_RS03070 (OI980_03070) 650624..651349 - 726 WP_008500116.1 MerR family transcriptional regulator -
OI980_RS03075 (OI980_03075) 651467..651991 + 525 WP_008500115.1 lipocalin family protein -
OI980_RS03080 (OI980_03080) 652070..653116 + 1047 WP_045352831.1 class I SAM-dependent methyltransferase -
OI980_RS03085 (OI980_03085) 653183..653620 + 438 WP_045352830.1 acetyltransferase -
OI980_RS03090 (OI980_03090) 653650..653949 - 300 WP_045352829.1 helix-turn-helix transcriptional regulator Antitoxin
OI980_RS03095 (OI980_03095) 653946..654299 - 354 WP_045352827.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OI980_RS03100 (OI980_03100) 654730..655071 - 342 WP_045352825.1 SymE family type I addiction module toxin -
OI980_RS03105 (OI980_03105) 655155..655352 + 198 WP_045352823.1 toxin-antitoxin system HicB family antitoxin -
OI980_RS03110 (OI980_03110) 655365..656222 - 858 WP_045352822.1 WYL domain-containing protein -
OI980_RS03115 (OI980_03115) 656402..656572 + 171 WP_164725120.1 hypothetical protein -
OI980_RS03120 (OI980_03120) 657069..657881 - 813 WP_045352820.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(42-80)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13508.45 Da        Isoelectric Point: 8.8479

>T262015 WP_045352827.1 NZ_CP109727:c654299-653946 [Enterobacter roggenkampii]
VDGSVRFGKVFEQWLFEQEEGLQDKVLADLLNLQHYGPRLPRPYADTVKGSRYKHMKELRIQYAGRPVRAFFAFDPVRQA
IVLCAGDKSNDKTFYEKMIRIADAEFSLHLTSQEAAK

Download         Length: 354 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11146.05 Da        Isoelectric Point: 8.0121

>AT262015 WP_045352829.1 NZ_CP109727:c653949-653650 [Enterobacter roggenkampii]
VKTLNEVIASRSPESQQRIKEMAEEMILETGLQLLREELRLSQKKVADLMGVSQPAVTQIEQRGNELKIATLKRYIEAMG
GKLCIDVELPTGKRVAFHI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1H8WUL1

References