Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3152597..3153254 Replicon chromosome
Accession NZ_CP109694
Organism Enterobacter asburiae strain 2017-45-54-05

Toxin (Protein)


Gene name higB Uniprot ID A0A808IF03
Locus tag OI909_RS15420 Protein ID WP_033146338.1
Coordinates 3152597..3152896 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A808ICP3
Locus tag OI909_RS15425 Protein ID WP_033146339.1
Coordinates 3152907..3153254 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI909_RS15410 (OI909_15405) 3148967..3151165 + 2199 WP_284592831.1 type I secretion system permease/ATPase -
OI909_RS15415 (OI909_15410) 3151176..3152345 + 1170 WP_086374946.1 HlyD family efflux transporter periplasmic adaptor subunit -
OI909_RS15420 (OI909_15415) 3152597..3152896 + 300 WP_033146338.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OI909_RS15425 (OI909_15420) 3152907..3153254 + 348 WP_033146339.1 HigA family addiction module antitoxin Antitoxin
OI909_RS15430 (OI909_15425) 3153299..3153724 + 426 WP_033146340.1 nucleoside triphosphatase NudI -
OI909_RS15435 (OI909_15430) 3153696..3154427 - 732 WP_207167826.1 helix-turn-helix transcriptional regulator -
OI909_RS15440 (OI909_15435) 3154525..3154944 + 420 WP_182072763.1 nuclear transport factor 2 family protein -
OI909_RS15445 (OI909_15440) 3154947..3155465 - 519 WP_182072765.1 hypothetical protein -
OI909_RS15450 (OI909_15445) 3155550..3156730 - 1181 Protein_3036 PLP-dependent aminotransferase family protein -
OI909_RS15455 (OI909_15450) 3156751..3157638 - 888 WP_182072767.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-86)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11691.32 Da        Isoelectric Point: 10.0346

>T262005 WP_033146338.1 NZ_CP109694:3152597-3152896 [Enterobacter asburiae]
MISYFRDQWLEDFFLYGRSSNVIPANLETALARKLDIIRAATSHRDLRSPPGNMYEALNPPLKGYSSIRVNRQYRLVFRW
TEGKAEDLYLSPHKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13066.02 Da        Isoelectric Point: 7.0134

>AT262005 WP_033146339.1 NZ_CP109694:3152907-3153254 [Enterobacter asburiae]
MTLQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLNLQLNVD
IWEAQSNPRTQEELSRIKTVADVMAKRKSGQPDVA

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808IF03

Antitoxin

Source ID Structure
AlphaFold DB A0A808ICP3

References