Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4392442..4393102 Replicon chromosome
Accession NZ_CP109692
Organism Enterobacter asburiae strain 2017-45-80

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OI907_RS21590 Protein ID WP_033145931.1
Coordinates 4392442..4392795 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1Z3MX79
Locus tag OI907_RS21595 Protein ID WP_029741460.1
Coordinates 4392800..4393102 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI907_RS21570 (OI907_21550) 4388584..4389501 + 918 WP_033145933.1 nitrogen assimilation transcriptional regulator NAC -
OI907_RS21575 (OI907_21555) 4389598..4390548 + 951 WP_023336219.1 HTH-type transcriptional regulator Cbl -
OI907_RS21580 (OI907_21560) 4390592..4391200 - 609 WP_080277780.1 glutathione S-transferase family protein -
OI907_RS21585 (OI907_21565) 4391371..4392264 + 894 WP_033145932.1 LysR substrate-binding domain-containing protein -
OI907_RS21590 (OI907_21570) 4392442..4392795 + 354 WP_033145931.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OI907_RS21595 (OI907_21575) 4392800..4393102 + 303 WP_029741460.1 XRE family transcriptional regulator Antitoxin
OI907_RS21600 (OI907_21580) 4393178..4394098 - 921 WP_033145930.1 LysR family transcriptional regulator -
OI907_RS21605 (OI907_21585) 4394240..4394629 + 390 WP_033145929.1 RidA family protein -
OI907_RS21610 (OI907_21590) 4394921..4395178 + 258 WP_033145928.1 antitoxin -
OI907_RS21615 (OI907_21595) 4395179..4395511 + 333 WP_033145927.1 type II toxin-antitoxin system PemK/MazF family toxin -
OI907_RS21620 (OI907_21600) 4395468..4395662 - 195 WP_080277779.1 hypothetical protein -
OI907_RS21625 (OI907_21605) 4395832..4397193 - 1362 WP_003036316.1 HEPN/Toprim-associated domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4383912..4412537 28625


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13577.40 Da        Isoelectric Point: 8.0361

>T261989 WP_033145931.1 NZ_CP109692:4392442-4392795 [Enterobacter asburiae]
VWAINTTDRFDRWFTSLDDTDRASVLAALLVLREKGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFDPNRTGI
MLCAGNKVGNERRFYDEMLLVADQEFTHWLDRLKERE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11050.83 Da        Isoelectric Point: 5.7316

>AT261989 WP_029741460.1 NZ_CP109692:4392800-4393102 [Enterobacter asburiae]
MGRTLEQLIADEKPEVVASAQAIATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MX79

References